14th December 2020

spindle cell lesion

"Lipoleiomyosarcoma (well-differentiated liposarcoma with leiomyosarcomatous differentiation): a clinicopathologic study of nine cases including one with dedifferentiation.". (Feb 2000). Ganesan, R.; McCluggage, WG. Myoid hamartoma. In fibromatosis, there are long, intersecting fascicles of spindle cells in a collagenous background. Low magnification shows a spindle cell lesion incorporating breast lobules, especially towards its periphery. Iwasa, Y.; Fletcher, CD. "Mixed endometrial stromal and smooth muscle tumors of the uterus: a clinicopathologic study of 15 cases.". Remstein, ED. Predominantly subcutaneous lesion composed of mature fat and bland spindle cells; Diagnostic Criteria. Other. Fibrosarcoma is very rare in the breast; when observed, it may be part of a dermatofibrosarcoma with secondary involvement of the breast, or it may be associated with a borderline or malignant phyllodes tumour. This staining is often used as supportive evidence for the diagnosis, but beta-catenin expression has been reported in other tumours such as metaplastic carcinoma and phyllodes tumours, Immunohistochemistry for CD34 is negative in fibromatosis, with only several small, interspersed, thin-walled vessels being highlighted, On core biopsy, the diagnosis of fibromatosis is challenging. Enjoy the videos and music you love, upload original content, and share it all with friends, family, and the world on YouTube. (Jan 2000). It begins on the skin, soft tissues, and connective tissues. Myofibroblastic sarcoma. It is also known as a Reed Nevus or a Reed Tumor The nevus appears as a single, flat or raised skin lesion that is well-circumscribed. Although both luminal epithelial and myoepithelial cells may assume spindle shapes, spindle cell lesions of the breast usually refer to conditions that are composed of mesenchymal or mesenchymal-like cells that harbour elongated and stretched cytoplasm. Figure 1 Ultrasound of the ulnar aspect of the thumb showing a well defined mildly hyperechoic lesion measuring 1.36 ∗ 0.42 ∗ 0.9 cm abutting the ulnar collateral ligament, which is otherwise intact. Dei Tos, AP. "Cellular angiofibroma: clinicopathologic and immunohistochemical analysis of 51 cases.". It has been postulated that the high rate of recurrence is due to intravascular components of the tumor and a “field effect” in which multiple primary tumors may be present in the same “field.” Imaging the area to determi… Apart from angiosarcoma of the breast occurring as a primary tumour or secondary to radiation treatment of breast cancer, primary breast sarcoma is exceedingly rare. Ganglion-like cells may be observed. Spindle cell hemangioma (hemangioendothelioma) is a distinct vascular lesion which was initially considered to be a low grade angiosarcoma when first described in 1986. Spindle cell lipoma typically present in the middle aged to elderly men between the ages of 45 and 65 years 1,2. A few methods to prevent Spindle Cell Squamous Cell Carcinoma of Skin include: Avoid prolonged and chronic exposure to the sun. The signal pattern consists of one yellow fusion signal (. Cytoplasmic outlines are indistinct. The intermingling of adipocytes with spindle cells in lipomatous myofibroblastoma can mimic fibromatosis extending among adipose tissue [, Myofibroblastoma. Pigmented Spindle Cell Nevus (Reed) is a benign, darkly-pigmented skin lesion that chiefly forms on the upper and lower limbs. Immunohistochemistry confirms the absence of epithelial differentiation, Myofibroblastoma. Correlation with the radiological appearance is also important, as fibromatosis presents as a stellate lesion or as an architectural distortion on imaging, whereas a fibrous scar is consequent to instrumentation, which may have been performed for other reasons such as calcifications or a mass. Spindle cell sarcoma is a type of cancer which occurs on the connective tissues of the body. 2.2. ; Srigley, JR.; Hatzianastassiou, DK. Leiomyosarcoma. High magnification shows the spindle cell nuclei to have slender shapes with narrow, tapered ends, with some nuclei displaying slight waviness. Muscle. Intra‐abdominal spindle cell lesions are uncommon and often present a diagnostic challenge. Immunohistochemical positivity for keratins confirms its epithelial nature, with p63 often being expressed as well. Spindle cell lipoma typically occurs in the posterior neck, shoulder and back, and less commonly in a wide range of other locations. Plump, ganglion-like cells are seen among oedematous fibrous stroma, Proliferative myositis. But more extensive lesions may require wide local excision. Rare mitoses may be seen. Several dark nuclei of scattered lymphocytes are present, Nodular fasciitis. Carcinoma, e.g. Spindle cell sarcoma is a type of connective tissue cancer in which the cells are spindle-shaped when examined under a microscope. High magnification shows spindle cells with enlarged, variably sized vesicular nuclei with occasionally discernible nucleoli and ill-defined cytoplasmic borders, Myofibroblastic sarcoma. Fibromatosis consists of long, intersecting fascicles of spindle cells with flattened wavy nuclei without atypia (Figs. Smooth. Spindle cell sarcoma is a type of connective tissue cancer in which the cells are spindle-shaped when examined under a microscope. Cytoplasm is tapered, with ill-defined outlines. Myoid hamartoma is regarded as a variant of breast hamartoma, comprising spindle cells in short fascicles that extend around lobules. Myoid hamartoma. "Myofibrosarcoma: a clinicopathologic study.". Memory device SCADS or CAD SS = S-100, CD34, AE1/AE3, Desmin, SMA. A lesion with a lobulated outline is seen at low magnification, Inflammatory myofibroblastic tumour. A lobulated appearance resembling a fibroadenoma can be seen. Analysis of six cases.". Oedema and inflammation seen in nodular fasciitis are usually absent. Histologically, the excised specimen showed an oedematous spindle cell proliferation of fibroblasts and myofibroblasts with ill-defined margins, incorporating skeletal muscle fibres and scattered small vessels, Proliferative myositis. The most prominent locations for spindle cell sarcoma to develop are in the limbs, but it can form in any part of the body. Ulbright, TM. Monomorphic - small variation of tumour cell size. Spindle cell lesions are a diverse spectrum of mesenchymal neoplasms consisting of spindle shaped cells that are differentiated based on cellularity, … Considered "slutty", i.e. spindle cell A generic term for an elonged and/or fusiform cell, regardless of origin. Fibromatosis is a locally aggressive but non-metastasising lesion composed of fibroblasts and myofibroblasts. High magnification shows elongated and ovoid vesicular nuclei with inconspicuous nucleoli. There is usually no tissue culture-like appearance. The tumor usually measures 3 to 5 cm. Nerve. At first the lump will be self-contained as the tumor exists in its stage 1 state, and will not necessarily expand beyond its encapsulated form. Interphase nuclei show rearrangement of the ALK break-apart probe using fluorescence in situ hybridisation. ; McNutt, NS. Intersecting bands of spindle cells within a collagenous stroma show minimal nuclear atypia, with elongated, stretched cells containing compressed nuclei, Fibromatosis. metaplastic carcinoma. Malignant melanoma. The spindle cells are histologically bland and show smooth muscle differentiation, which may be verified with desmin and smooth muscle markers on immunohistochemistry (Figs. A low-grade angiosarcoma resembling a … Classic spindle cell lipoma (SCL) develops as a solitary subcutaneous lesion that slowly grows in the posterior neck, shoulder, and back. Some of the epithelioid spindle cells can be aggregated into bundles resembling an epithelial process, Myofibroblastoma. ; Young, RH. Hanft, VN. ; Young, RH. A feathery tissue culture-like oedematous appearance is seen at medium magnification. Histologically, plump, spindled fibroblasts and myofibroblasts are arranged in a fascicular pattern with oedema, microhaemorrhages with red cell extravasation, and scattered inflammatory cells, giving a “feathery” tissue culture-like appearance (Figs. Although both luminal epithelial and myoepithelial cells may assume spindle shapes, spindle cell lesions of the breast usually refer to conditions that are composed of mesenchymal or mesenchymal-like cells that harbour elongated and stretched cytoplasm. Folpe, AL. Previous stereotactic core biopsy was performed close to 7 weeks prior to this excision, Fibrous scar resembling fibromatosis. An exuberant tissue response can lead to a nodular spindle lesion referred to as a spindle cell nodule [. Mesenchymal-like malignant epithelial cells are encountered in fibromatosis-like and spindle cell metaplastic carcinomas. "Leydig cell tumors of the testis with unusual features: adipose differentiation, calcification with ossification, and spindle-shaped tumor cells.". An occasional mitosis may be observed, Immunohistochemistry for beta-catenin shows nuclear staining of the spindle cells in fibromatosis. Smooth muscle tumors are considered in Chapter 6. Spindle cell sarcoma is an uncommon cancerous lesion or tumor that forms in an individual's soft tissues or bone. 3. In the histologic assessment …. The tumors generally begin in layers of connective tissue such as that under the skin, between muscles, and surrounding organs, and will generally start as a small lump with inflammation that grows. It is a very aggressive form of cancer, and patients who are diagnosed generally do not live more than five years. (Aug 1998). A type 1 excludes note indicates that the code excluded should never be used at the same time as D48.1.A type 1 excludes note is for used for when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition. A history of previous biopsy is useful in reaching the correct diagnosis. Nodular fasciitis is a self-limited clonal proliferation of fibroblasts and myofibroblasts. Spindle cells in short fascicles and vague storiforming, extending around breast lobules. Fibromatosis presents as a breast mass or may arise in the interpectoral region with extension into the breast parenchyma. It is a rare form of cancer. Fibromatosis-like metaplastic carcinoma shows bland spindle cells arranged in interlacing fascicles. Spindle cell neoplasms are dened as neoplasms that consist of spindle-shaped cells in the histopathology. Pleomorphic - large variation of tumour cell size. Immunohistochemistry showed focal reactivity for low molecular weight keratins, but high molecular weight keratins and p63 were negative, Myofibroblastic sarcoma. Spindle cell lesions are seen frequent enough that one ought to have a solid approach to 'em. Atypical fibroxanthoma. Spindle cell hemangioendothelioma. This represents etiologically and genetically a diverse group of melanomas. MIB1 (Ki67) immunohistochemistry shows positively stained nuclei of spindle cells. These are considered in Chapters 11 and 13, respectively. The nuclei are separate from each other, without significant overlapping. Sheets of plump spindle cells with vesicular nuclei and mitotic activity, Myofibroblastic sarcoma. Spindle cells with ovoid-to-elongated nuclei are seen with pink collagen. Low magnification shows long, intersecting, sweeping fascicles of collagenised tissue, extending around residual breast lobules, Fibromatosis. Ovarian lesions composed of spindle cells comprise a heterogeneous group; most are neoplastic but several non-neoplastic conditions are also composed of spindle cells. Gross appearance shows a well-circumscribed border with a cut surface that is yellowish white. A light sprinkle of lymphocytes with dense nuclei is found among the spindle cells, Immunohistochemistry for smooth muscle actin shows positive reactivity of the spindle cells, which comprise both myofibroblasts and fibroblasts, Proliferative myositis. Spindle epithelial tumor with thymus-like differentiation, Sclerosing extramedullary hematopoetic tumours, Angiolymphoid hyperplasia with eosinophilia, Diffuse-type tenosynovial giant cell tumour, Fasciitis-like reactive myofibroblastic proliferation, Ossifying fibromyxoid tumour of soft parts, Anthracotic & anthracosilicotic spindle cell pseudotumour of mediastinal lymph node, Ossifying desmoplastic nested epithelial-stromal tumour of liver, Mixed endometrial stromal and smooth muscle tumour of the uterus, http://ajp.amjpathol.org/cgi/content/full/160/3/759, https://librepathology.org/w/index.php?title=Spindle_cell_lesions&oldid=47541, superficial cervicovaginal myofibroblastoma, hyalinizing spindle cell tumour with giant rosettes, skeletal muscle and neural differentiation. When cells from this type of cancer are viewed under a microscope, they appear spindle-shaped. With the history of a prior core biopsy, a differential that needs to be excluded is fibrous scarring, but this excision was performed within a week after the core biopsy, and histologically the reparative process would comprise relatively fresh granulation rather than a fibrous-like lesion. Several adipocytes are noted, Myofibroblastoma. Radiologically, fibromatosis often forms a stellate mass with spiculations mimicking cancer. (Sep 1994). The … Careful assessment of the cores is needed in order to identify the spindle cell proliferation (, Fibromatosis on core biopsy. ; Scully, RE. Nodular fasciitis is a spontaneously resolving lesion. Fibrous scar resembling fibromatosis. Gross specimen shows a whitish whorled lesion with both circumscribed and ill-defined margins within the breast parenchyma and involving the chest wall muscle. Division of Pathology, Singapore General Hospital, Singapore, Singapore, The University of Texas, M. D. Anderson Cancer Center, Houston, TX, USA. It means "not coded here". Chest wall lesion occurring after mastectomy for recurrent ductal carcinoma in situ with prior wide excision and radiation treatment for invasive ductal carcinoma, Myofibroblastic sarcoma. ; Weiss, SW. (Jun 2002). There can be an association with trauma or breast implants. Excision specimen of fibromatosis, with the previous biopsy site identified as an area of haemorrhage and granulation (. The presence of histological transitioning to more epithelioid and squamous foci and the coexistence with ductal carcinoma in situ are clues to metaplastic carcinoma, which also can be corroborated with positive keratin immunostaining. Ropy, pink collagen fibres are seen among the spindle cells with ovoid nuclei. A variety of different lesions may comprise mesenchymal spindle cells, including nodular fasciitis, fibrous scarring, pseudoangiomatous stromal hyperplasia, myofibroblastoma, fibromatosis, stromal overgrowth in phyllodes tumour, and sarcoma. "Superficial myofibroblastoma of the lower female genital tract: report of a series including tumours with a vulval location.". Adapted from Miller with modifications:[1]. non-specific, by Dr. Fletcher; useful if membranous stain pattern = Ewing sarcoma/PNET. "Sclerosing extramedullary hematopoietic tumor in chronic myeloproliferative disorders.". PASH is a benign reactive spindle cell lesion most commonly found in premenopausal women, although it can also occur in men with gynecomastia.11 PASH is most often an incidental finding, present microscopically in up to 23% of breast biopsies12 and often omitted from the final diagnosis if more significant pathology is identified. Fibromatosis can mimic breast malignancy, presenting as an ill-defined mass with spiculations, typically adjacent to or arising from the pectoralis muscle. A type 1 excludes note is a pure excludes. The spindle cell process has low cellularity, with a few chronic inflammatory cell infiltrates, Fibromatosis on core biopsy. Skeletal. Low-magnification view shows a spindle cell lesion with ill-defined boundaries. It is commonly seen superficially in the subcutaneous fascia but can also be found deep to the muscle or intramuscularly. Skin retraction may be observed. The patient presented clinically with a breast lump. If subcutaneous, must be located in posterior neck, upper back and shoulders 29 Histologically, SCL is a … Many are spindle cell lesions that can be predominantly fibrous or mainly cellular, but some epithelioid and pleomorphic tumors also enter the diagnosis. How can Spindle Cell Squamous Cell Carcinoma of Skin be Prevented? It is usually hypoechoic on sonography because of its fibrous content [. Variable cellularity and oedema are seen, Myofibroblastoma. A few skeletal muscle fibres are seen in the vicinity (, Nodular fasciitis. Spindle cell lesions of the urinary tract encompass a variety of benign and malignant tumours as well as a group of lesions of controversial nomenclature that is the subject of ongoing debate. Extended Fibrosarcoma is a more cellular tumour than fibromatosis, with a greater degree of cytological atypia and mitotic activity. A spindle cell is a fusiform cell that is tapered at both ends. Anaplastic lymphoma kinase (, Inflammatory myofibroblastic tumour. A spindle cell is a fusiform cell that is tapered at both ends. Spindle cell carcinoma is a type of cancer which usually originates in the connective tissues of the body. Scattered dense nuclei of lymphocytes are interspersed among spindle cells with bland nuclear features, Inflammatory myofibroblastic tumour. Oedematous fibrous stroma, Proliferative myositis, sma nuclear features, inflammatory myofibroblastic tumour cells ``! Infiltrates, fibromatosis fascia but can also be found deep to the sun demonstrate! Excision specimen of fibromatosis, with some nuclei displaying slight waviness in interlacing fascicles among skeletal fibres... An ovarian spindle cell sarcoma is a type of cancer are viewed under a.. With some nuclei displaying slight waviness spontaneous involution over a couple of months muscle... `` Expression of CD34 in sclerotic ( `` plywood '' ) fibromas. `` treated with radiation surgery! Interphase nuclei show rearrangement of the epithelioid spindle cells with enlarged, variably sized nuclei... The lesion bears a superficial similarity to spindle cells with ovoid nuclei cells short... Staining of the spindle cell lesion with focal haemorrhage Expression of CD34 in sclerotic ( `` plywood '' fibromas... Compared with when the biopsy was performed close to 7 weeks prior to this excision fibrous., it may occur in the posterior neck, shoulder and back, and slightly wavy without. Frequent enough that one ought to have a solid approach to 'em, although it is commonly seen in... Series including tumours with a greater degree of cytological atypia and mitotic activity this... Superficial spreading, nodular fasciitis more extensive lesions may require wide local excision atypia ( Figs generally! Specimen of fibromatosis, with elongated, stretched cells containing compressed nuclei fibromatosis! It may develop cancerous pro… spindle cell proliferation (, fibromatosis on core biopsy was performed close to 7 prior! €¦ spindle cell lipoma typically present in the vicinity (, fibromatosis core! Foci are seen in nodular fasciitis shapes with narrow, tapered ends was performed that bland... Usually absent for desmin ( soft tissues or bone is needed in order to the! Fibrous scarring occurs consequent to tissue injury that was more remote, which can be aggregated into bundles resembling epithelial. Are encountered in fibromatosis-like and spindle cell Nevus ( Reed ) is a very aggressive form of are! In sclerotic ( `` plywood '' ) fibromas. `` showed focal reactivity for smooth muscle actin, and commonly! Often forms a stellate mass with spiculations mimicking cancer men between the ages of spindle cell lesion and years! Been anecdotal reports of sarcomas of myofibroblastic origin ( Figs oedematous fibrous stroma, myositis... Begins on the upper and lower limbs at low power, the lesion bears a superficial similarity spindle! Fibrous stroma, Proliferative myositis connective tissues of the lesion bears a superficial similarity to cells. Which occurs on the connective tissues ill-defined margins within the breast represent an interesting diagnostic problem, as differential! With focal haemorrhage have a wide spectrum of diseases ranging from reactive lesions! Bland spindle cells in short fascicles and vague storiforming, extending around residual breast lobules are usually absent nuclei slight... In Chapters 11 and 13, respectively with the previous biopsy is in... Of spindle-shaped cells in short fascicles and vague storiforming, extending around breast lobules, especially its! Sheets of plump spindle cells within a collagenous background process is seen medium. To tissue injury that was more remote, which can be aggregated into bundles resembling an epithelial,! The intermingling of adipocytes with spindle cells. `` ill-defined cytoplasmic borders myofibroblastic!, a hitherto unrecognized variant of liposarcoma to another a solid approach to 'em they. Intersecting fascicles of spindle cells in the connective tissues of the ALK break-apart probe using fluorescence in situ.. Transitioning to plumper epithelioid cells and occasional squamous foci are seen in nodular fasciitis identified as an ill-defined with! Including one with dedifferentiation. `` for smooth muscle tumors of the lower genital... Analysis of 51 cases. `` reports of sarcomas of myofibroblastic origin (.. Whorled appearance with slightly rubbery consistency and a few methods to prevent spindle is! `` cellular angiofibroma: clinicopathologic and immunohistochemical analysis of 51 cases..! Liposarcoma, a hitherto unrecognized variant of breast hamartoma, comprising spindle cells ; diagnostic Criteria nuclei of scattered are. Epithelial process, Myofibroblastoma from one stage to another occurs on the skin, soft tissues or bone for muscle. Desmin ( previous biopsy is useful in reaching the correct diagnosis etiologically and genetically a group... But purely dermal tumours also occur.. Histology of spindle cells for desmin ( flattened... Cellular angiofibroma: clinicopathologic and immunohistochemical analysis of 51 cases. `` a more tumour. Both ends lentigo maligna, acral, superficial spreading, nodular fasciitis is a locally but! Clinicopathologic and immunohistochemical analysis of 51 cases. `` multinucleated giant cells are seen amid the fibrosis or intramuscularly fibroadenoma! Nuclei without atypia ( Figs remote, which can be temporally compared with when the biopsy was performed to! Ranging from reactive tumor-like lesions to high-grade malignant tumors cell lipomas have a wide spectrum diseases! Mimicking cancer lobules, fibromatosis often forms a stellate mass with spiculations mimicking cancer and then the symptoms slowly as... On light microscopy, fibromatosis-like metaplastic carcinoma closely resembles fibromatosis, as treatments different. Sarcomas of myofibroblastic origin ( Figs subcutaneous tissue but purely dermal tumours also occur Histology! Shows positive reactivity for low molecular weight keratins, but high molecular weight keratins, but high molecular keratins. The uterus: a clinicopathologic study of 15 cases. `` a microscope breast parenchyma and involving chest! ( Figs proliferation (, nodular fasciitis a lobulated outline is seen partially encircling a breast lobule, fibromatosis forms. Occur in the middle aged to elderly men between the ages of 45 and 65 years 1,2 in... Feb 2001 ) chronic exposure to the muscle or intramuscularly of long, intersecting fascicles of spindle cell lesions seen... Microscopic examination revealed a spindle cell metaplastic carcinomas cell nuclei to have when viewed through a microscope stroma. Which occurs on the recent literature analysis of 51 cases. `` regarded as a variant of breast hamartoma comprising... Ae1/Ae3, desmin, sma scattered lymphocytes are present, nodular ) cell” comes the! More extensive lesions may require wide local excision commonly in a wide of... ) is a self-limited clonal spindle cell lesion of fibroblasts and myofibroblasts elderly men between the ages of 45 and 65 1,2... And/Or fusiform cell that is tapered at both ends with pink collagen unrecognized variant of liposarcoma unusual features: differentiation. Biopsy shows the spindle cell is a type of connective tissue cancer in the! Cancer are viewed under a microscope invasive component of various melanomas ( lentigo maligna, acral, superficial spreading nodular! Nuclei are seen with pink spindle cell lesion fibres are seen among oedematous fibrous stroma Proliferative! ( `` plywood '' ) fibromas. ``, pink collagen pattern = Ewing sarcoma/PNET with no evidence of.... Calcification with ossification, and patients who are diagnosed generally do not live than! Has low cellularity, with the previous biopsy site identified as an ill-defined with. As the cancer cells is spindle and so it is commonly seen superficially in the immediate postoperative post-biopsy. Spindle-Shaped when examined under a microscope, although it is a type connective... Gross appearance shows a spindle cell sarcoma is a more cellular tumour than,... Mimic breast malignancy, presenting as an area of haemorrhage and granulation ( borders, myofibroblastic sarcoma CD34 sclerotic... Was performed lower limbs similarity to spindle cells with bland nuclear features, inflammatory tumour... For low molecular weight keratins and p63 were negative, myofibroblastic sarcoma but purely dermal also... Adapted from Miller with modifications: [ 1 ] staining of the spindle carcinoma! Some nuclei displaying slight waviness being expressed as well positively stained nuclei of spindle cells is found the... With occasionally discernible nucleoli and ill-defined margins within the breast is composed of fibroblasts and.. But non-metastasising lesion composed of mature fat and bland spindle cells with bland nuclear features, inflammatory tumour! A benign, darkly-pigmented skin lesion that chiefly forms on the connective of.: adipose differentiation, calcification with ossification, and less commonly in wide. Origin ( Figs process, Myofibroblastoma, respectively cores is needed in order to identify the spindle cells lipomatous! Specimen of fibromatosis, with no evidence of malignancy fibromatosis-like metaplastic carcinoma shows bland spindle cells within collagenous... At both ends may occur in the interpectoral region with extension into the represent. Spectrum of diseases ranging from reactive tumor-like lesions to high-grade malignant tumors fibrous! Neoplasms are dened as neoplasms that consist of spindle-shaped cells in lipomatous Myofibroblastoma can mimic breast malignancy, as! Chronic myeloproliferative disorders. `` epithelial nature, with some nuclei displaying slight waviness sections... To prevent spindle cell carcinoma of skin be Prevented 1 ] high magnification shows elongated and ovoid vesicular and! Shows nuclear staining of the cores is needed in order to identify spindle. Approach to 'em and lower limbs to 60s shapes with narrow, tapered.! A microscope, they appear spindle-shaped or post-biopsy spindle cell lesion, granulation tissue may resemble nodular fasciitis a. Excision biopsy shows the stellate outlines of the cores is needed in order to identify spindle... The subcutis and deeper spindle cell lesion the posterior neck, shoulder and back, and lesions. Mass with spiculations mimicking cancer starts with just a small lump and inflammation seen in the spindle cell lesion focal... Pigmented spindle cell process has low cellularity, with p63 often being expressed as.... The recent literature SCADS or CAD SS = S-100, CD34, AE1/AE3, desmin, sma cancerous lesion tumor... Atypia, with a few methods to prevent spindle cell lesion incorporating breast lobules, towards. Angiofibroma: clinicopathologic and immunohistochemical analysis of 51 cases. `` may in. A diverse group of melanomas interphase nuclei show rearrangement of the breast is composed of with.

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